This will be Vilsack's first run for elected office. She considered running for U.S. Senate against longtime Republican incumbent Chuck Grassley in 2010. But she gave way to former Democratic candidate for governor, Roxanne Conlin, who later failed to make the contest close.
Here's the story I did earlier in the day where Iowa Governor Terry Branstad said Vilsack would be a "fish out of water" if she moved to the 4th District. The story also shows Vilsack's husband, Tom's, reaction when we tried to get him to talk about his wife's plans.